Publications

Starnes GL, Jewett TJ, Carruthers VB, Sibley LD. Two separate, conserved acidic amino acid domains within
the Toxoplasma gondii microneme protein 2 cytoplasmic tail are required for parasite survival.
J. Biol. Chem. 2006 PMID: 16923803

Khan A, Bohme U, Kelly KA, Adlem E, Brooks K, Simmonds M, Mungall K, Quail MA, Arrowsmith C,
Chillingworth T, Churcher C, Harris D, Collins M, Fosker N, Fraser A, Hance Z, Jagels K,
Moule S, Murphy L, O'Neil S, Rajandream MA, Saunders D, Seeger K, Whitehead S, Mayr T, Xuan X,
Watanabe J, Suzuki Y, Wakaguri H, Sugano S, Sugimoto C, Paulsen I, Mackey AJ, Roos DS, Hall N,
Berriman M, Barrell B, Sibley LD, Ajioka JW. Common inheritance of chromosome Ia associated with
clonal expansion of Toxoplasma gondii. Genome Res. 2006 16:1119-25. PMID: 16902086
Supplemental files: ChrmIa.pdf

Boyle JP, Rajasekar B, Saeij JP, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, Boothroyd JC.
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like
Toxoplasma gondii. Proc. Natl. Acad. Sci. (USA). 2006 103:10514-9. PMID: 16801557

Nagamune K, Sibley LD. Comparative genomic and phylogenetic analyses of calcium ATPases and
calcium-regulated proteins in the apicomplexa. Mol. Bio.l Evol. 2006 23:1613-27. PMID: 16751258
Supplemental files: CaBinding.aln CaBinding.ps CDPK.aln CDPK.ps PATPase.aln PATPase.ps
VGCC.aln VGCC.ps.

Khan A, Jordan C, Muccioli C, Vallochi AL, Rizzo LV, Belfort R Jr, Vitor RW, Silveira C, Sibley LD. Genetic
divergence of Toxoplasma gondii strains associated with ocular toxoplasmosis, Brazil.
Emerg. Infect. Dis. 2006 12:942-9. PMID: 16707050

Gordon JL, Sibley LD. Comparative genome analysis reveals a conserved family of actin-like proteins in
apicomplexan parasites. BMC Genomics. 2005 Dec 12;6(1):179 PMID: 16343347 Supplemental files:
092105ArpSuperfamily.aln 092105ArpSuperfamily.ps

SahooN, Beatty W, Heuser J, Sept D, Sibley LD. Unusual kinetic and structural properties control rapid assembly

and turnover of actin in the parasiteToxoplasma gondii, Mol Biol Cell. 2005, Nov 30, PMID: 16319175

Wetzel DM, Schmidt J, Kuhlenschmidt MS, Dubey JP, Sibley LD. Gliding motility leads to active cellular invasion

by Cryptosporidium parvum sporozoites. Infect Immun. 2005, 73,5379-87. PMID: 16113253

Chini EN, Nagamune K, Wetzel DM, Sibley LD. Evidence that the cADPR signalling pathway controls

calcium-mediated microneme secretion inToxoplasma gondii Biochem J., 2005, 389, 269-77.

PMID: 15773818

Robben PM, Laregina M, Kuziel WA, Sibley LD. Recruitment of Gr-1+ monocytes is essential for control of acute

toxoplasmosis. J Exp Med. 2005 Jun 6;201(11):1761-9. Epub 2005 May 31. PMID: 15928200

Khan A, Taylor S, Su C, Mackey AJ, Boyle J, Cole R, Glover D, Tang K, Paulsen IT, Berriman M, Boothroyd JC,

Pfefferkorn ER, Dubey JP, Ajioka JW, Roos DS, Wootton JC, Sibley LD. Composite genome map and

recombination parameters derived from three archetypal lineages of Toxoplasma gondii. Nucleic Acids

Res. 2005, 33(9):2980-92. PMID: 15911631 Supplemental files: 15911631.pdf

Barragan A, Brossier F, Sibley LD. Transepithelial migration of Toxoplasma gondii involves an interaction of

intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2. Cell Microbiol. 2005,

7(4):561-8. PMID: 15760456

Brossier F, Jewett TJ, Sibley LD, and Urban S: A spatially-localized rhomboid protease cleaves cell surface
adhesions essential for invasion by Toxoplasma. Proc. Natl. Acad. Sci. (USA), 2005, 102, 4146-4151.
　　　PMID: 1575328

Charron AJ, Sibley LD: Molecular partitioning during host cell penetration by Toxoplasma gondii. Traffic, 2004,
5, 865-867. PMID: 15479452

Wetzel DM, Chen LA, Ruiz FA, Moreno SNJ, Sibley LD: Calcium-mediated protein secretion potentiates motility
byToxoplasma gondii. J. Cell Sci., 2004, 117, 5739-5748. PMID: 15507483

Sibley LD: Intracellular Parasite Invasion Strategies. Science, 2004, 304, 248-253. PMID: 15073368
Supplemental files: 15073368SOM.pdf

Jewett TJ and Sibley, LD: The Toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for
intracellular survival. J. Biol. Chem. 2004, 279, 9362-9369. PMID: 14670959

Morrissette NS, Das A, Sept D, Sibley LD: Dinitroanilines bind alpha-tubulin to disrupt microtubules. Molec. Biol.
Cell, 2004, 15, 1960-1968. PMID: 14742718

Robben PM, Mordue DG, Truscott SM, Takeda K, Akira S, Sibley LD: Induction of IL-12 by macrophages infected
with Toxoplasma gondii depends on the parasite genotype. J. Immunol., 2004, 172, 3686-3694.
PMID: 15004172

Su CL, Evans D, Cole RH, Kissinger JC, Ajioka JW, LD Sibley Enhanced oral transmission acquired through recent
recombination led to widespread expansion of Toxoplasma. Science, 2003, 299: 414-416.
PMID: 12532022 Supplemental files: 125320022SOM.pdf

Li L, Brunck B, Kissinger J, Pape D, Martin J, Wylie T, Dante M, Tang K, Cole R, Fogarty S, Howe D, Liberator P,
Diaz C, White M, Jerome ME, Johnson EA, Radke JA, Haywood RE, Chakrabarti D, Waterston R, Clifton S,
Roos D, LD Sibley Comparative gene expression in the Apicomplexa revealed by EST sequence analyses.
Gen. Res., 2003, 13: 443-454. PMID: 12618375

Jewett TJ, and LD Sibley Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in
apicomplexan parasites. Molec. Cell, 2003, 11: 885-894. PMID: 12718875

Brossier F, Jewett TJ, Lovett JL, and LD Sibley C-terminal processing of TgMIC2 is essential for invasion of host
cell by Toxoplasma gondii. J. Biol. Chem., 2003, 278: 6229-6234. PMID: 12471033

Wetzel D, Håkansson S, LD Sibley Actin filament polymerization regulates gliding motility by apicomplexan
parasites. Molec. Biol. Cell. 2003, 14, 396-406. PMID: 12589042

Su CL, Howe DK, Dubey JP, Ajioka J, LD Sibley Acute Virulence in Toxoplasma is Mediated by Several Discrete
Loci Common to the Type I Lineage. Proc. Natl. Acad. Sci. USA, 2002, 99: 10753-10758. PMID: 12149482
Supplemental files: 12149482SOM.pdf

Barragan A, Sibley LD: Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence.
J. Exp. Med., 2002,195: 1625-1633. PMID: 12070289

Lovett Jl, Moreno SNJ, LD Sibley Toxoplasma gondii microneme secretion involves intracellular Ca⁺² release from
IP3/ryanodine sensitive stores. J. Biol. Chem., 2002, 277: 25870-25876. PMID: 12011085

Mercier C, Dubremetz JF, Rauscher B, Lecordier L, LD Sibley, Cesbron-Delauw MF, Biogenesis of a nanotubular
network in the Toxoplasma parasitophorous vacuole induced by parasite proteins. Molec. Biol. Cell, 2002,
13:2397-2409. PMID: 12134078

Mordue DM, Monroy F, La Regina M, Dinarello C, LD Sibley Acute toxoplasmosis leads to lethal over-production
of Th1 cytokines. J. Immunol. 2001, 167: 4574-4584. PMID: 11591786

Håkansson S, Charron AJ, LD Sibley 2001 Toxoplasma evacuoles: a two step process of secretion and fusion
forms the parasitophorous vacuole. EMBO J. 20: 1-13. PMID: 11406590

Carruthers VB, Sherman GD, LD Sibley 2000 The Toxoplasma adhesive protein MIC2 is proteolytically processed
at multiple sites by two distinct parasite-derived proteases. J. Biol. Chem. 275, 14346-14353.
PMID: 10799515

Mordue D, Desai N, Dustin M, LD Sibley 1999 Invasion by Toxoplasma gondii establishes a moving junction that
selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring.
J. Exp. Med. 190, 1783-1792. PMID: 10601353

Håkansson S, Morisaki H, Heuser JE, LD Sibley 1999 Time-lapse video microscopy of gliding motility in
Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion. Molec. Biol. Cell, 10:
3539-3547. PMID: 10564254

Mordue D, and LD Sibley 1997 Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the
time of formation and depends on the mechanism of entry. J. Immunol. 159: 4452-4459. PMID: 9379044

Dobrowolski J, and LD Sibley. 1996 Toxoplasma invasion of mammalian cells is powered by the parasite's actin
cytoskeleton. Cell 84: 933-939. PMID: 8601316

Sibley LD, M Messina, and IR Niesman. 1994 Stable transformation in the obligate intracellular parasite
Toxoplasma gondii by complementation of tryptophan auxotrophy. Proc. Natl. Acad. Sci. (USA) 91:
5508-5512. PMID: 8522178

Sibley LD, and JC Boothroyd. 1992. Virulent strains of Toxoplasma gondii comprise a single clonal lineage.
Nature (Lond.) 359: 82-85. PMID: 1355855

Sibley LD, Krahenbuhl,JL, Adams GMW, and E Weidner. 1986. Toxoplasma modifies macrophage phagosomes
by secretion of a vesicular network rich in surface proteins. J. Cell Biol. 103: 867-874. PMID: 3528173

Sibley LD, Weidner E, and JL Krahenbuhl. 1985. Phagosome acidification blocked by intracellular
Toxoplasma gondii. Nature (Lond.) 315: 416-419. PMID: 2860567